Metforlip/Metforlip SR Dosage/Direction for Use

Metformin (Metforlip) should be given in divided doses (2-3 times/day) with meals while metformin hydrochloride extended-release tablets (Metforlip SR) should generally be given once daily with the evening meal. In both cases it should be started at a low dose, with gradual dose escalation, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient.
Recommended Dosing Schedule: Metforlip: Adults: The usual starting dose of Metforlip is 500 mg twice a day, given with meals. Dosage increments should be made by 500 mg weekly, up to a total of 2000 mg per day, given in divided doses. Patients can also be titrated from 500 mg twice a day to 850 mg twice a day after 2 weeks.
Pediatrics: The usual starting dose of Metforlip is 500 mg twice a day, given with meals. Dosage increases should be made in increments of 500 mg weekly up to a maximum of 2000 mg per day, given in divided doses.
Metforlip SR: Adults: The usual starting dose of Metforlip SR (Metformin hydrochloride extended-release tablets) is 500 mg once daily with the evening meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal. If glycemic control is not achieved on Metforlip SR 2000 mg once daily, a trial of Metforlip SR 1000 mg twice daily should be considered.
In a randomised trial, patients currently treated with Metformin were switched to Metformin extended-release tablets (Metforlip SR). Results of this trial suggest that patients receiving Metformin treatment may be safely switched to Metformin extended-release tablets (Metforlip SR) once daily at the same total daily dose, up to 2000 mg once daily. Following a switch from Metformin to Metformin extended-release tablets (Metforlip SR), glycemic control should be closely monitored and dosage adjustments made accordingly.
Children: not recommended.